Cancer drug cisplatin was accidentally discovered to help treat cancer in 1965. Jul 18, 2017 for directions for the administration of cyclophosphamide, refer to the cyclophosphamide package insert. Cisplatin for injection is a platinumbased drug indicated for the treatment of. Platinol cisplatin for injection, usp should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
See full prescribing information for complete boxed warning. Premedicate with antiemetic agents see dosage and administration 2. Appropriate management of therapy and complications is. Save money on your platinolaq injection prescription by switching to tevas fdaapproved generic version, cisplatin injection. Cisplatin injection infusion concentrate is a clear, colorless, sterile aqueous solution available in amber vials.
All caregivers should take safety precautions while giving this drug. The name of your medicine is cisplatin 1 mgml concentrate for solution for infusion but in the rest of the leaflet it will be called cisplatin injection. Without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated with cisplatin for injection and may be so severe that. Cisplatin for injection is a highly emetogenic antineoplastic agent. See chemotherapy nephrotoxicity and dose modification in patients with kidney impairment. A randomized trial of cisplatin, etoposide and bleomycin peb versus carboplatin, etoposide and bleomycin ceb for patients with goodrisk metastatic nonseminomatous germ cell. A transitionmetal complex that is used in the treatment of cancer, with particular effectiveness in the treatment of testicular and ovarian cancers explanation of cisplatin. Hearing loss more common in children, bleeding problems, a decrease in your bodys ability to fight infections bone marrow suppression, and severe nausea and vomiting may occur as. Cisplatin is a chemotherapy medication used to treat a number of cancers.
Current status and new developments is a collection of papers presented at a symposium sponsored by the university of alabama in birmingham comprehensive cancer center and the bristol laboratories in syracuse. Use is contraindicated in those patients with a history of allergic reaction to cisplatin or other platinum containing compounds, or any component of the formulation. Cisplatin, the active ingredient in cisplatin injection, is a yellow to orange crystalline powder with the molecular formula cl 2 h 6 n 2 pt and a molecular weight of 300. The ptiv derivative of cisplatin with one axial aspirin and one. Paraplatin carboplatin for injection, usp is supplied as a sterile, lyophilized white powder available in singledose vials containing 50 mg, 150 mg, and 450 mg of carboplatin for administration by intravenous infusion. To view the cisplatin molecule in 3din 3d with jsmol. Cisplatin is also being studied in the treatment of other types of cancer. Jul 18, 2017 cisplatin injection sisplat in common brand names. Cisplatin can cause fetal harm when administered to a pregnant woman. Cisplatin is an anticancer agent with some side effects. Oct 18, 2019 if cisplatin is used in combination chemotherapy, the dose of cisplatin must be reduced. Cisplatin is in a class of drugs known as platinumcontaining compounds used to treat various types of cancers including metastatic testicular.
Mar 01, 2019 cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Cisplatin is mutagenic in bacteria and produces chromosome aberrations in animal cells in tissue culture. A novel camptothecin analogue fl118 reduces cisplatin resistance. A typical dose is 20 mgm 2 or more once every 3 to 4 weeks unless in the combination therapy of smallcell and nonsmallcell lung carcinoma, in which a typical dose of 80 mgm 2 is administered. Package insert of accord healthcares cisplatin injection. Each vial of platinol contains 50 mg cisplatin, 450 mg sodium chloride, usp, and 500 mg mannitol, usp. Cisplatin may give allergic reactions in some patients. Medlineplus information on cisplatin a lay language summary of important information about this drug that may include the following.
Happy 50th anniversary to cisplatin, the drug that changed. Apexbio cisplatininhibits dna synthesis,chemotherapy. Highlights of prescribing information reduce the dose of. Cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Cisplatin, cisplatinum or cisdiamminedichloridoplatinumii cddp is a platinumbased chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas e. Cisplatin comes as a liquid that is injected into a vein over six to eight hours in a hospital or medical facility. Patients received 20 mgm 2day of cisplatin for 5 days and 80 mgm2day of etoposide or etoposide phosphate. Each vial contains equal parts by weight of carboplatin and mannitol. Anderson cancer center, 1515 holcombe boulevard, houston, tx 770304009, usa cisplatin is one of the most potent antitumor agents. The discovery and development of cisplatin article pdf available in journal of chemical education 835 may 2006 with 4,236 reads how we measure reads. As the firstline drug therapy for nonsmall cell lung cancer nsclc, cisplatin has a wide range of ap plications. Cisplatin is used to treat various types of cancer. Each 50 ml or 100 ml amber vial of infusion concentrate contains.
Cisplatin side effects will improve after therapy is complete. Sigmaaldrich offers a number of cisplatin products. Cisplatin, the active ingredient in cisplatin for injection, usp, is a yellow to orange crystalline powder with the molecular formulacl 2 h 6 n 2 pt and a molecular weight of 300. Highlights of prescribing information platinumresistant. Cisplatin 1 mgml sterile concentrate should be diluted in 2 litres of 0. Cisplatin fda prescribing information, side effects and uses. Cisplatin also called platinol is an anticancer medicine. Pdf a randomized trial of cisplatin, etoposide and. Cisplatin article about cisplatin by the free dictionary. An average urine output of at least 100mlhr must be maintained throughout treatment, and cisplatin infusion should not be commenced unless this. Cad was the least stable compound, with 50% degradation after the. As a single agent, cisplatin cisplatin injection should be administered at a dose of 100 mgm 2 iv per cycle once every four weeks. Your dosage will be based on your medical condition, weight, and response to the. The use of cisplatin in patients with preexisting kidney dysfunction and the renal effects of the platinum analogs, carboplatin and oxaliplatin, are discussed elsewhere.
Cisplatin may cause severe kidney problems or very serious allergic reactions. Pfizer rxpathways connects eligible patients to a range of assistance programs to help them access their pfizer prescriptions. Original article the chemosensitization effect of quercetin on cisplatin induces the apoptosis of human colon cancer ht29 cell line wei jin 1, haiming han, lan ma2, hongmei zhou, cunxin zhao1 1department of gastroenterology, yidu central hospital of weifang, weifang 262500, p. Apexbio cisplatininhibits dna synthesis,chemotherapy drug. It is used alone or in combination with other medications to slow or stop cancer cell growth. Recommended dose modifications in patients with cervical cancer. Cisplatin dosing, indications, interactions, adverse effects. This medication is usually given by injection into a vein by a health care professional. The recommended dose of alimta when administered with cisplatin in patients with a creatinine clearance calculated by cockcroftgault equation of 45mlmin or greateris 500mgm2 as an intravenous infusion over 10minutes on day 1 of each 21day cycle until disease progression or unacceptable toxicity. Numerous mechanisms of cisplatin resistance were described including changes in cellular uptake, drug efflux, increased detoxification, inhibition of apoptosis and increased dna repair. Alimtais a folate analog metabolic inhibitor indicated. Avastin, in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is indicated for the treatment of patients with persistent, recurrent, or metastatic cervical cancer.
At the recommended dosage, platinol should not be given more frequently than once every 3 to 4 weeks see adverse reactions. Docetaxel and cisplatin regimen for nonsmallcell lung cancer. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. The active ingredient, cisplatin, is a yellow to orange crystalline powder with the. Doxorubicincisplatinloaded superparamagnetic nanoparticles as a stimuli responsive codelivery system for chemophotothermal therapy. A total of 121 patients were randomized and 120 treated 60 per group. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. The problem with coadministration of several drugs is that each drug has a different. To view the cisplatin molecule in 3d in 3d with jsmol. Cisplatin is fda approved alone or in combination with other drugs to treat people who have certain types of cancer.
Cisplatin dosing, indications, interactions, adverse. Only select registry of toxic effects of chemical substances rtecs data is presented here. In combination therapy, cisplatin cisplatin injection and cyclophosphamide are administered sequentially. Cisplatin cisplatin injection drug overview and uses for. These include testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two. Nevertheless, due to the nonspecificity and high dosage of drugs in. Anaphylacticlike reactions to cisplatin such as facial edema, bronchoconstriction, tachycardia, and hypotension have been reported and may occur within minutes of cisplatin administration. Package insert of accord healthcares cisplatin injection, 1 mgml, 50 ml and 100 ml.
Lung pathway group pemetrexed and cisplatin in nonsmall. Cisplatin gains entry into tubular cells via uptake by the oct2 system on the basolateral membrane of proximal tubular cells. Due to the unprecedented nature of the covid19 pandemic, anyone reporting an adverse event andor a product complaint via phone, should you receive a network busy signal ie. The contents of klk7 and ecad in tumor tissue and serum of tumorbearing mice in four groups were different group a. Full text doxorubicincisplatinloaded superparamagnetic. For 48 hours after this drug is given, the patients body fluids can contain the drug. Experiment research of cisplatin implants inhibiting transplantation. See actual entry in rtecs for complete information. The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and.
May 28, 2019 hypersensitivity to cisplatin or to any of the excipients listed in section 6. Cisplatin is a commonly used chemotherapy drug and intravenous administration is the most commonly. Should be administered only by or under the direct supervision of a qualified physician who is experienced in the use of cancer chemotherapeutic agents. See manufacturers prescribing information for cisplatin administration and hydration guidelines and for cisplatin dosage adjustment in the event of hematologic toxicity. In general, for severe grade 3 or 4 nonhematological toxicity, except alopecia and nauseavomiting, therapy with gemcitabine for injection plus cisplatin should be held or decreased by 50% depending on the judgment of the treating physician. Adverse reaction or laboratory values recommended dose modification.
And its been doing exactly that since it was approved for use in 1978. To minimize cisplatin resistance, combinatorial therapies were. Carboplatin carboplatin this product information is intended only for residents of the united states. Appropriate management of therapy and complications is possible only when adequate. It is given by injection into a vein common side effects include bone marrow suppression, hearing problems, kidney problems.
Exercise caution to prevent inadvertent cisplatin overdose as doses greater than 100 mgm2cycle once every 3 to 4 weeks are rarely used. Cisplatin side effects are often predictable in terms of their onset, duration, and severity. The parent compound, cisplatin, is excreted in the urine and accounts for % to 17% of the dose excreted within one hour after administration of 50 mgm2. Tumor tissue was collected and homogenized after adding pbs.
Jun 01, 2015 cisplatin injection is a clear, lightyellow, sterile aqueous solution available in amber vials containing 1 mgml of cisplatin. Cisplatin is a platinumbased agent whose nephrotoxicity is thought related to the chloride in the cis position. For directions for the administration of cyclophosphamide, refer to the cyclophosphamide package insert. Cisplatinbased doublets are recommended for adjuvant and neoadjuvant treatment of potentially operable nonsmallcell lung cancer nsclc and firstline therapy for advanced or metastatic nsclc. Highlights of prescribing information these highlights do not include all the information needed to use. If cisplatin accidentally seeps out of the vein into which it is injected, it may damage some tissues and cause scarring. Cisplatin 1 mgml sterile concentrate summary of product. Mar 10, 2015 cancer drug cisplatin was accidentally discovered to help treat cancer in 1965. There are many options to help minimize or prevent the side effects of cisplatin. It is believed to induce apoptosis through several mechanisms. Cellular apoptosisnecrosis develops due to endoplasmic reticuluminduced stress, mitochondrial injury pathways, and a death receptor pathway. Cisplatin investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen. Jul 09, 20 cisplatin based doublets are recommended for adjuvant and neoadjuvant treatment of potentially operable nonsmallcell lung cancer nsclc and firstline therapy for advanced or metastatic nsclc.
Fl118, anticancer activity, cisplatin resistance, nsclc, survivin, emt. To minimize cisplatin resistance, combinatorial therapies were developed and have proven more effective to defeat cancers. The latest nmr studies on the wellknown anticancer drug cisplatin, with focus on. The traditional mechanism is that cisplatin enters the cell, interacts with the dna guanine bases and forms the inter or intrastrand chain crosslinking, then prevents the replication of dna. Weight should be recorded prior to and at the end of cisplatin treatment, and a strict fluid balance chart should be maintained. In this study, we aimed to demonstrate the effects of the addition of cisplatin which is a widely used antineoplastic drug for osteosarcoma, on the mechanical properties of bone cement, and to evaluate the cytotoxic effects of eluted cisplatin on saos2 cell culture. Cisplatin side effects, dosage, interactions drugs.
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